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Nowadays, dozens of interventions are known that extend the lifespan of various living organisms ranging from yeast to mammals. They include chemical compounds, genetic interventions, and diets. Some targets of these interventions have been discovered. However, there is still no clear understanding of the systemic molecular mechanisms leading to lifespan extension. A group of scientists from Skoltech, Moscow State University and Harvard University decided to fill this gap and identify crucial molecular processes associated with longevity. To do so, they looked at the effects of various lifespan-extending interventions on the activity of genes in a mouse, a commonly used model organism closely related to humans. “In our lab, we subjected mice of different sexes and ages to 8 longevity interventions and analyzed gene expression changes induced by these treatments. After aggregating our data with the datasets published by other groups, we obtained gene activity profiles of 17 interventions. Although in general the effects produced by individual treatments turned out to be rather specific, a certain group of genes changed its expression in a similar way in response to different lifespan-extending interventions,” says the first author of the study, Alexander Tyshkovskiy. The scientists then applied the discovered biomarkers to search for other interventions with the same effect on their activity and, therefore, high potential for lifespan extension "Currently, we are validating these hits by testing their effect on the mouse lifespan. We hope that our biomarkers will significantly facilitate the search for new longevity interventions and help improve the healthspan and lifespan in rodents and, in the long term, in humans," says Alexander. 
5. The word “validating” in paragraph 4 is closest in meaning to ______

Mark the letter A, B, C, or D on your answer sheet to indicate the undelined part that needs correction in each of the following questions:
Shyness may not seem to be a serious complaint, but for some who suffer from it, it can become unbearable. Even talking to a small group of people you know can seem like an ordeal - it can feel as if you’ve been asked to give a speech on a topic you know very little about to a number of experts. You start to feel hot and shaky, your heart beats faster, your knees feel weak, you begin to stutter and the whole experience seems to last forever.
The fact of the matter is that shyness is something we often recognize in others: blushing is one of the more visible signs, for example. Yet we do not judge someone harshly because of this. But shyness does mean you are harder to approach, so you become more isolated. As one shy person put it, “It’s like being in a prison, and it’s very hard to break out.”
Experts on the subject have come up with various possible solutions, and one has been singled out as being the key to success, namely, finding an interest in common with other people. Spending a lot of time on the sidelines watching other people and envying them because they are much more outgoing doesn’t help; remembering that some of the people you envy most are probably shy themselves. The secret is how you deal with it. And experts have come up with four things you can do today to help. Firstly, you can start by listening to other people. You will find yourself getting interested in what they’re talking about and asking questions, and before you know it, you’ll be having a conversation. Secondly, you could try asking neighbors if you can walk their dog. Like children, pets can be excellent icebreakers for conversations with passers-by. Thirdly, try joining a class to learn something like tap-dancing or flamenco, where people are likely to laugh a lot. You’ll feel relaxed, and also you’ll be much too busy concentrating on what you are doing to feel shy. Lastly, try telling yourself that it doesn’t matter if you say or do something silly. Most people make a fool of themselves every so often, and it’s not the end of the world if you do

One of the symptoms of shyness in a stressful situation is      

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Scientists believe that something very serious is happening to the Earth. It is becoming warmer. Scientists predict that there will be major changes in the climate during the 21st century. Coastal waters will have higher temperatures. This will have a serious effect on agriculture. Farmers will have trouble producing good crops. In warm regions, the weather will be too dry. The amount of water could decrease by 50 per cent. This would cause a large decrease in agricultural production. World temperatures could increase from 1.5 to 5.6 degrees Celsius by the middle of the 21st century. And the increase in temperature could be even greater in the Arctic and Antarctic regions. A rise in temperature could cause the great ice sheets to melt, which, in turn would raise the level of oceans by one to two meters. Many coastal cities would be underwater. Why is all this happening? The Earth and its atmosphere are kept warm by the Sun. The atmosphere lets most of the light from the Sun pass through to warm the Earth. The Earth is warmer by the sunlight and sends heat energy back into the atmosphere. Much of this energy escapes from the Earth’s atmosphere. However, some of it remains. Gases such as carbon dioxide, ozone and water vapor absorb this energy and create more heat. Then, this heat is sent back down to Earth, and the Earth becomes warmer. Recently, however, an increase of carbon dioxide in the atmosphere is causing serious problems. Too much carbon dioxide in the atmosphere prevents heat energy from escaping. Too much heat is sent back down to the Earth, and the amount of carbon dioxide in the atmosphere continues to increase. When oil, gas, and coal burn, they create large amounts of carbon dioxide. The destruction of rain forests that absorb carbon dioxide also helps to increase the amount of carbon dioxide in our atmosphere. Some scientists believe that the amount of carbon dioxide in the air will double by the late 2000s. Scientists call this warming of the Earth and its atmosphere “the greenhouse effect”. A greenhouse, made of glass and plastic, is a special place where plants are grown. The sunlight passes through the glass or plastic and warms the air inside. The heat inside escapes very slowly, so the greenhouse remains very warm. This is exactly what is happening on the Earth. Another reason why the Earth is growing warmer is because of the amount of ozone in our atmosphere. Ozone is a form of oxygen. In the upper atmosphere, very far from the Earth, a layer of ozone helps to protect the Earth from 95 percent of the harmful light that comes from the sun. If your skin receives too much of this light, you would develop skin cancer. We need the ozone layer to protect ourselves. But the ozone layer is in trouble. Scientists have observed that the ozone layer is becoming thin, and above Antarctica there is a hole. This allows too much of the sun’s dangerous light into our atmosphere and makes the Earth warmer. Scientists say we must start making changes and planning now. We need to continue to do research, so we can predict what will happen in the future. We must burn less coal, oil, and gas. Other scientists believe that the problem is not so serious. They think that the Earth is growing warmer naturally, that we don’t need to worry about it now, and that we should just get ready for life in the warmer climate. Most scientists agree that the causes of the world’s climate are very complicated. They say that we must continue to measure the amount of carbon dioxide and ozone in the atmosphere. Scientists also encourage people to learn about the changes that are occurring in the world and how we can all help protect our atmosphere  
4. The Earth wouldn’t become warmer if ____

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Graphic novels, as the name suggests, are books written and illustrated in the style of a comic book. Adults may feel that graphic novels do not help children become good readers. They believe that this  type of  reading material  somehow prevents  "real"   reading. (1)_____ , many quality graphic novels are now being seen as a method of storytelling on the same level as novels, films or audiobooks. Many librarians and teachers are now accepting graphic novels as proper literature for children as they (2)____ young people and motivate them to read. This has been especially true with children who are not (3)_________to read, especially boys.Language learners are also motivated by graphic novels because the pictures provide clues to the meaning of the words. Therefore, they will (4)______ new vocabulary more quickly. Many teachers have reported great success when they used graphic novels with their students, especially in the areas of English, social studies and art. The idea that graphic novels are too simple to be regarded as serious reading is no longer valid. Reading them can, undoubtedly, help students develop the skills (5) _____ are necessary to read more challenging works

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Paul Watson is an environmental activist. He is a man who believes that he must do something, not just talk about doing something. Paul believes in protecting endangered animals, and he protects them in controversial ways. Some people think that Watson is a hero and admire him very much. Other people think that he is a criminal. On July 16th, 1979, Paul Watson and his crew were on his ship, which is called the Sea Shepherd. Watson and the people who work on the Sea Shepherd were hunting on the Atlantic Ocean near Portugal. However, they had a strange prey, instead of hunting for animals, their prey was a ship, the Sierra. The Sea Shepherd found the Sierra, ran into it and sank it. As a result, the Sierra never returned to the sea. The Sea Shepherd, on the other hand, returned to its home in Canada. Paul Watson and his worked thought that they had been successful. The Sierra had been a whaling ship, which had operated illegally. The captain and the crew of the Sierra did not obey any of the international laws that restrict whaling. Instead, they killed as many whales as they could, quickly cut off the meat, and froze it. Later, they sold the whale meat in countries where it is eaten. Paul Watson tried to persuade the international whaling commission to stop the Sierra. However, the commission did very little, and Paul became impatient. He decided to stop the Sierra and whaling ships in any way that he could. He offered to pay $25,000 to an one who sank any illegal whaling ship, and he sank the Sierra. He acted because he believed that the whales must be protected. Still, he acted without the approval of the government; therefore, his action controversial. Paul Watson is not the only environmental activist. Other men and women are also fighting to protect the Earth. Like Paul Watson, they do not always have the approval of their governments, and like Watson, they have become impatient. Yet, because of their concern for the environment, they will act to protect it.
3. The members of a ship's crew are: 

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Bagpipe music played, wreaths were sent and Amazing Grace was sung. A  black shroud was laid upon a makeshift urn. It was a funeral, of course, for which such displays of respect are common. But in this case, the people living in a small Nova Scotia community had gathered to pay their respects not to a person who had died, but to a post office.  The grief might have been hard for outsiders to understand, but not for those living in Head of St. Margaret’s Bay, N.S., where the post office run by Verna Dunlop was a big part of their small, tight-knit community. The post office, which had been located in the back of Dunlop’s home, was not just a utilitarian service kiosk where residents had to go to pick up their mail. According to locals, it was also a community hub where people gathered to catch up on the town gossip, or to enjoy a cup of the coffee the postmaster had been brewing for them. “It’s really the centre of the village,” said one woman, explaining what the post office meant to the people living there.  There had been a post office located in Head of St. Margaret’s Bay since before Confederation. And local residents spent months fighting to keep the one they had. But Canada Post made the decision to close it, as it was losing money. It was replacing the post office with sets of newly installed super mailboxes.  Many people in town weren’t convinced the coming changes were for the better. “We do not want those super mailboxes. We want to have a community life,” he said. At the mock funeral, Dunlop choked up as she said she hoped “this is going to stop,” alluding to the fact that it wasn’t just Head of St. Margaret’s Bay that was losing its post office. “We hope that the way of life that we’re used to we can keep,” she added. Canada Post had closed 40 such rural post offices that year and had long-term plans to close more than 5,000 of them across the country. “Just as Verna Dunlop’s post office came to symbolize for these people the best qualities of rural life, so does its passing remind them of the steady erosion of that way of life,” said Evans.
1. What is the main topic of the passage?

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Books have been around for thousands of years. When ancient civilizations first started developing writing systems, they would write on just about anything, from stone to tree bark. Ancient Egyptians were the first to use paper-like materials, called “papyrus”, which they made by pounding flat the woven stems of the papyrus plant. It was not long before the ancient Egyptians began gluing together papyrus sheets to form scrolls, which were the first steps toward books as you know. The birthplace of bookbinding is considered to be India in the 2nd century B.C., where Hindi scribes would bind palm leaves that were etched with religious texts between two wooden boards using twine. The technique became popular in the Middle East and Eastern Asia, and spread to the Romans by the 2nd century A.D. In the mid-15th century, German Johannes Gutenberg invented the first mechanical printing press. His invention was revolutionary because it enabled mass production of booksfor the first time. Before the printing press, a few pages per day could be produced by handcopying. Afterward, printing presses could produce as many as 3,600 pages per day. Today, modern publishers take advantage of incredible advances in technology to produce books in many sizes and shapes very quickly. Although there are many types of processes and machines available, most processes involve similar steps. Printers print the text of a book on large sheets of paper, sometimes as large as a newspaper page. Working with large volumes of paper allows printers to lower costs and produce books more efficiently.The large sheets are then cut into smaller pages that are still about twice the size of a finished book. The smaller pages are then divided into small groups, folded in half, and sewn together. Lastly, the folded and sewn pages are cut down to their finished size and glued to the spine of the final book’s cover. Depending on the quality of the book, additional finishing touches may be added, such as blank pages at the front and back of the book or special tape around the edges of the cover to increase durability. Although printed books may never go away completely, today’s readers will most certainly soon become more familiar with e-books. “E-book” refers to an electronic book, which is simply the text of a book displayed electronically, either via the Internet, a CD-ROM, a tablet, an e-book reader, or even a mobile phone. As electronic devices, such as tablets and mobile phones, become more commonplace, e-books are expected to become more and more popular. One of the benefits of e-books is that they save paper, which helps the environment by reducing the demand for trees  
1. Which of the following does the passage mainly discuss?

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Air pollution is the most prominent and dangerous form of pollution. It occurs dues to many reasons. Excessive burning of fuel which is a necessity of our daily lives for cooking, driving and other industrial activities releases a huge amount of chemical substances in the air every day; as a result, these pollute the air. Smoke from chimneys, factories, vehicles or burning of wood basically occurs due to coal burning. This releases sulphur dioxide into the air making it toxic. The effects of air pollution are evident too. Release of sulphur dioxide and hazardous gases into the air causes global warming and acid rain which in turn have increased temperatures, erratic rains and droughts worldwide making it tough for animals to survive. We breathe in every polluted particle from the air, the result is an increase in asthma and cancer in the lungs. Another effect of air pollution is ozone layer depletion. Ozone layer is the thin shield high up in the sky that prevents ultra violet rays from reaching the Earth. As a result of human activities, chemicals, such as chlorofluorocarbons (CFCs) which play a key role, were released into the atmosphere which contributed to the destruction of ozone layer. Water pollution has taken toll of all the surviving species of the earth. Almost 60% of the species live in water bodies. It occurs due to several factors; the industrial wastes dumped into the rivers and other water bodies cause an imbalance in the water leading to its severe contamination and death of aquatic species. If you suspect that nearby water sources have been contaminated by a corporation then it might be a good idea to hire an expert to see you options. Moreover, spraying insecticides, pesticides like DDT on plants also pollutes the ground water system and oil spills in the oceans have caused irreparable damage to the water bodies. Eutrophication is another big source; it occurs due to daily activities like washing clothes or utensils near lakes, ponds or rivers; this forces detergents to go into water which blocks sunlight from penetrating, thus reducing oxygen and making it inhabitable. Water pollution not only harms the aquatic beings but it also contaminates the entire food chain by severely affecting humans dependents on these. Waterborne disease like cholera, diarrhea have also increased in all places. Another type of pollution common in the countryside is soil pollution. Soil pollution occurs due to the incorporation of unwanted chemicals in the soil due to human activities. Insecticides and pesticides absorb the nitrogen compounds in the soil making it unfit for plants to derive nutrition. Release of industrial waste, mining and deforestation also damages the soil. Since plants can’t grow properly, they can’t hold the soil and this leads to soil erosion.
5. What is NOT mentioned as a cause of water pollution?

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We’re not surprised if you haven’t been following the recent developments in AI all  that closely because, for the most part, it’s seemed like nothing exciting has happened for quite a long time. Sci-fi dreams about computer powered best friends aside, AI for the general public has come to mean reasonably responsive and well-programmed computer assistance rather than independent thinking machines. Concepts like ‘smart’ chatbots somehow seem to pull us further from the Star Trek or Heinlinian dream of fully sentient and intuitive computers while many products and services that claim to integrate AI seem to be nothing more than a fast way to analyze large amounts of data.  In fact, the last time most of us heard something hopeful about AI was when Deep Blue beat the world Chess champion, but what ever came of that AI? Surely it hasn’t used that incredible logical power to take over the world or begin making friends, so what do we even care?  While practical applications for specifically built AI are growing, the tradition of training your AI programming skills on classic strategy games has existed since the 1950s when a computer was programmed to play and was able to win a game of tic-tac-toe. Since then a large variety of games and custom-built AIs have been tested against each other to the great entertainment of experts in the field and curious nerds like us who care about that sort of thing. The real difference is not what they’re programmed for but how they are programmed to start with and, in fact, this is also what most profoundly distinguishes AlphaGo from its older-generation relative, the Chess champion DeepBlue. 
1. Which best serves as the title for the passage?

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Like many social and political movements, the green movement has been  strengthened and annealed by the forces that oppose it. After James Watt was appointed to lead the Department of the Interior, for instance, membership in the Sierra Club grew from 183,000 to 245,000 in just 12 months.  Today, the green movement is again defined and galvanized by its command of issues like global warming and climate change, wetlands preservation, the Keystone pipeline, nuclear proliferation, hydraulic fracturing or “fracking,” fisheries depletion, species extinction and other important environmental concerns.  What distinguishes the green movement today from the earlier conservation movement is its emphasis on science and research. Speaking in spiritual tones and using religious metaphors, early environmentalists like Muir and Thoreau celebrated nature for its profound impact on man’s emotions and our souls. When Hetch Hetchy Valley in California was threatened by a dam, Muir exclaimed, “Dam Hetch Hetchy! As well dam for water-tanks the people’s cathedrals and churches, for no holier temple has ever been consecrated by the heart of man.”  Now, however, we are far more likely to call upon scientific data and empirical research to buttress arguments in favor of wilderness preservation, or against polluting industries. Politicians cite the work of polar researchers and use computerized climate models  o battle global warming, and medical researchers rely on public health statistics to argue against mercury pollution. Whether these arguments succeed or fail, however, still depends on the vision, the passion and the commitment of the people who make up the green movement
5. According to paragraph 4, which statement generalizes the development of conservation movement?

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The print media includes newspapers, magazines, brochures, newsletters, books and even leaflets and pamphlets. Visual media like photography can also be mentioned under this sub-head, since photography is an important mass media, which communicates via visual representations. Although it is said that the electronic or new media have replaced the print media, there exists a majority of audiences who prefer the print media for various communication purposes. Public speaking and event organizing can also be considered as a form of mass media. For many people, it is impossible to imagine a life without their television sets, be it the daily news dose or even the soap operas. This mass media includes television and radio. This category also included electronic media like movies, CDs and DVDs as well as the new hottest electronic gadgets.  With the advent of new technologies like Internet, we are now enjoying the benefits of high technology mass media, which is not only faster than the old-school mass media, but also has a widespread range. Mobile phones, computers and Internet are often referred to as the new-age media. Internet has opened up several new opportunities for mass communication which include email, websites, blogging, Internet television and many other mass media which are booming today. Mass media was developed as a means of social responsibility at the beginning. However, in the course of time, they have attained the status of an industry. Besides the social and industrial nature of mass media, the following common points may also be mentioned. Specifically, it is highly impersonal, because the masses are not identifiable based on perfectly defined audio, visual or written messages. In addition, it is never likely to reach 100 percent of the target nor to have more than 10 percent effectiveness in most of the cases. Contents are generally based on the broad social issues and aspiration of the target audience which may be designed to achieve some specific goals; and all in all, modern mass media draw heavily on technology  
3. Which of the following is mentioned as a favourite TV programme?

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Practical experience is a must-have for today’s job seekers. According to Brazen Life’s Huffington Post article titled “Why Gaining Work Experience Is More Important Than Your Education,” many colleges and universities report that students who have completed an internship or gained work experience during their studies have higher rates of getting hired. For example, at Iowa State University, of all students who completed a co-op program to earn a BS in engineering, an astounding 90 percent got jobs after graduation. Why is practical experience so important? There are a number of reasons why you need practical work experience. First, it’s simply the smart thing to do when you’re preparing for a career in a specific field. Let’s say it’s your dream to work as a consultant for an international corporate relocation company because you love international travel and you like organizing things. So you get a part-time job working as an office assistant at a corporate relocation company… and you find out it’s very different from what you expected. In short, you realize this isn’t the job for you-and you can concentrate on finding another job where you can put your passion and skills to work, for example in the tourism industry. Alternatively, you might find out that you enjoy the corporate relocation business. That means you’re gaining invaluable industry experience that will look great on your resumé when you apply for a full-time job.  Second, practical work experience teaches valuable soft skills, such as discipline, perseverance, teamwork, leadership skills, communication skills and problem solving. Employers will look for these in candidates and they’ll want to see proof. If you’ve spent a month as a team leader at Homes for Heroes, the leadership skills, teamwork experience and problem-solving abilities you developed there can add significant value to your candidacy. Third, working helps you build your network and can provide you with contacts in your chosen field. These contacts can be extremely useful when it comes to hearing about job leads and interesting opportunities. In addition, if you’ve impressed someone, he or she might be willing to write you a letter of recommendation for a job or a place in a graduate program.  Finally, the company you’re working for might offer you a position after you’ve graduated. Your employer already knows your skills and abilities, and you’re already acquainted with the company-so it’s a win-win situation! 
6. Which of the following statements is TRUE, according to the passage?

Read the following passage and mark the letter A, B, C, or D on your answer sheet to indicate the correct answer to each of the questions:
Because writing has become so important in our culture, we sometimes think of it as more real than speech. A little thought, however, will show why speech is primary and writing secondary to language. Human beings have been writing at least 5,000 years, but they have been talking for much longer, doubtless ever since there have been human beings. When writing developed, it was derived from and represented speech, although imperfectly. Even today, there are spoken languages that have no written form. Furthermore, we all learn to talk well before we learn to write; any child who is not severely handicapped physically or mentally will learn to talk: a normal man cannot be prevented from doing so. On the other hand, it takes a special effort to learn to write; in the past, many intelligent and useful members of society did not acquire the skill, and even today many who speak languages with writing systems never learn to read or write while some who learn the rudiments of those skills do so imperfectly.
To affirm the primacy of speech over writing is not to disparage the later. One advantage writing has over speech is that it is more permanent and makes possible the records that any civilization must have. Thus, if speaking makes us human, writing makes us civilized.

In order to show that learning to write requires effort, the author gives the example of     .

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Globally we use more energy than ever before, and the demand is rapidly growing. Economic expansion of emerging market economies, population growth and our increasing use of energy-consuming devices are among the most important contributing factors. About one-third of the radiation hitting Earth’s atmosphere is reflected back out into space by clouds, ice, snow, sand and other reflective surfaces. The other two-thirds is absorbed by the Earth’s surface and the atmosphere. As the land, oceans and atmosphere heat up, they re-emit energy as infrared thermal radiation, which passes through the atmosphere. Heat-trapping gases like carbon dioxide (CO2) absorb this infrared radiation and prevent it from dissipating into space, giving rise to what we know as the greenhouse effect. The accumulation of CO2 and other greenhouse gases in the atmosphere is the dominating driver of recent climate change. CO2 is estimated to be responsible for 64 % of man-made global warming. Other greenhouse gases are released in much smaller amounts but still contribute significantly to the overall warming effect, as they are much more potent heat-trapping gases than CO2. The EU is taking action on many levels. One example is on fluorinated gases that are contributing less than CO2 but still a particular point of concern in addressing climate change. They are used in several types of products, such as in refrigeration, air-conditioning and heat pump equipment. While fluorinated gases are released into the atmosphere in smaller quantities than other greenhouse gases, they are extremely potent – they produce a warming effect 23 000 times greater than CO2. For this reason the EU has decided to control their use. The EU’s regulation on fluorinated greenhouse gases aims at cutting the Union’s emissions by two-thirds compared to 2014 levels. Chemicals are not only part of the problem – they are also part of the solution. Sustainable energy sources like solar power rely on chemical innovation using, for example, nanomaterials. One of the main challenges with renewable energy is how to increase its viability with the help of energy storage solutions. For example, solar panels have the best conditions in the desert, but that is not where most people live. Windmills also produce power during the night, which is when our energy consumption is at its lowest. In other words, technologies to improve energy storage and transportation is one of the important areas of research where innovation is needed  
1. The passage mainly discusses_________.

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Hardly a week goes by without some advance in technology that would have seemed  incredible 50 years ago. And we can expect the rate of change to accelerate rather than slow down within our lifetime. The developments in technology are bound to have a dramatic effect on the future of work. By 2010, new technology will have revolutionized communications. People will be transmitting messages down telephone lines that previously would have been sent by post. Not only postmen but also clerks and secretaries will vanish in a paper-free society. All the routine tasks they perform. will be carried on a tiny silicon chip so that they will be as obsolete as the horse and cart after the invention of the motor car. one change will make thousands, if not millions, redundant.  Even people in traditional professions, where expert knowledge has been the key, are unlikely to escape the effects of new technology. Instead of going to a solicitor, you might go to a computer which is programmed with all the most up-to-date legal information. Doctors, too, will find that an electronic competitor will be able to carry out a much quicker and more accurate diagnosis and recommend more efficient courses of treatment. In education, teachers will be largely replaced by teaching machines far more knowledgeable than any human being. Most learning will take place in the home via video conferencing. Children will still go to school though, until another place is created where they can make friends and develop social skills.  What can we do to avoid the threat of unemployment? We shouldn’t hide our heads in the sand. Unions will try to stop change but they will be fighting a losing battle. People should get computer literate as this just might save them from professional extinction. After all, there will be a few jobs left in law, education and medicine for those few individuals who are capable of writing and programming the software of the future. Strangely enough, there will still be jobs like rubbish collection and cleaning as it is tough to programme tasks which are largely unpredictable.
5. According to the passage, in the future children ______

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Why has Holmes continued to (1) _________________ generation after generation when other fictional detectives of the Victorian period are forgotten? One can break the answers down into a mix of elements. But first it will be useful to summarize the life of Holmes’s (2)____________. Doyle was born in Edinburgh in 1859, one of nine children of an alcoholic Irish artist who was consigned, in later life, to a lunatic asylum. Young Arthur Doyle was educated at the fee-paying Jesuit college, Stony Hurst. (3)___________ 16 he spent a year in Austria before enrolling at Edinburgh University’s medical school. In 1880 he spent seven months in the Arctic as ship’s doctor on a whaler. The following year he graduated with a (4)__________ degree, and made another trip to Africa before setting up, less adventurously, in medical practice near Portsmouth, in July 1882. His income had reached £300 a year by 1885, enabling him to marry the sister of one of his patients. Doyle had long written on the side and in 1886 he played around with stories (5)____________ on an ‘amateur private detec-tive’, called ‘J. Sherrinford Holmes’. The outcome was the Sherlock Holmes novella, A Study in Scarlet (1887). No top-drawer publisher would take it and it was eventually serialized as a Christmas giveaway in a magazine and then as what was called a ‘shilling shocker’ – pulp fiction for the masses

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A new method for analyzing DNA collected from waterways which can help identify endangered bird species has been developed with the help of researchers from The University of Western Australia. The DNA analysis method developed also with researchers from Charles Darwin University and the Northern Territory’s Department of Environment and Natural Resources provides a new way of understanding the distribution of endangered birds by analyzing DNA collected in the waterways where they drink. The research, which will be published in Endangered Species Research Journal, offers new possibilities to support conservation efforts and increase understanding of birds that are scarce and otherwise hard to capture data on. The team developed a probe to locate DNA in water samples of the critically endangered Gouldian Finch (Erythrura gouldiae), a rainbowcolored grassfinch endemic to the savanna woodlands of northern Australia. UWA Professor Simon Jarman from the School of Biological Sciences said the researchers thought it would be hard to detect bird DNA in tropical conditions where the rate of DNA breakdown was high. “We were also sampling from pools where the water was not flowing and there was a lot of sediment and algal and bacterial growth,” Professor Jarman said. “However we were really pleased to get reliable bird detections from our methods showing DNA can be used to detect many species from the poles to the equator.” Professor Jarman said the Gouldian Finch was a beautiful and iconic species that was endangered due to habitat loss from being hunted extensively. "The DNA method will help to map where the finches are currently found with great accuracy, which will help persuade people to conserve the areas where they live," he said.  
4. According to paragraph 3, why did Professor Simon Jarman describe the investigated area?

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In Viet Nam festivals often take place during the three months in spring and in autumn when people have a lot of leisure time. In addition, the climate in spring and autumn is especially suitable for holding festivals and for festivals goers to enjoy. Traditional festivals constitute a form of cultural activities, a spiritual product which the people have created and developed during the course of history. From generation to generation, the Vietnamese people preserve the fine tradition of “remembering the source while drinking water.” Festivals are events which represent this tradition of the community as well as honor the holy figures named as “gods” – the real persons in national history or legendary persons. The images of gods converge the noble characteristics of mankind. They are national heroes who fought against foreign invaders, reclaimed new lands, treated people, fought against natural calamities, or those legendary characters who affect the earthly life. Accordingly, first and foremost, festivals are events when people pay tribute to divinities that rendered merits to the community and the nation. These are occasions when people come back to either their natural or national roots, which form a sacred part in their mind. Furthermore, festivals represent the strength of the commune or village, the local region or even the whole nation. Worshipping the same god, the people unite in solidarity to overcome difficulties, striving for a happy and wealthy life. Moreover, festivals display the demand for creativity and enjoyment of spiritual and material cultural values of all social strata. Festivals become a form of education under which fine traditional moral values can be handed from one generation to the next in a unique way of combining spiritual characters with competition and entertainment games. Festivals are also the time people can express their sadness and worries in a wish that gods might bestow favor on them to help them strive for a better life.  
4. Which of the following is NOT mentioned as a value of festivals?

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Previously, people often only considered second-hand smoke as a welfare issue, focusing on the smell and the irritation that tobacco smoke causes to eyes, nose and throat. But now the weight of evidence for much more serious risks to health from second-hand smoke has grown too great to ignore. Tobacco smoke contains around 4,000 chemicals, including arsenic, benzene, formaldehyde and ammonia. Around 60 of these chemicals are known or suspected to cause cancer. Many of the toxic chemicals are actually more concentrated in the smoke that’s given off by the burning tip of a cigarette (sidestream smoke). Around 85 per cent of the smoke in a room where people are smoking is the more toxic sidestream smoke. By breathing in it in the atmosphere, the non-smoker is exposed to many of the same health risks as the smoker. The best known risk to smokers, lung cancer, is also more common in people regularly exposed to second-hand smoke. The Government’s Scientific Committee on Tobacco and Health (SCOTH) reported in 1998 that exposure to second-hand smoke increases the risk of lung cancer in non-smokers by 20-30 per cent. Even though they inhale only 1% of the smoke, non-smokers exposed to second-hand smoke may suffer 25 per cent of the increased risk of heart disease associated with active smoking (one recent study suggests it might be as much as 50 per cent). Just 30 minutes of breathing second-hand smoke can reduce the coronary blood supply of a non-smoker to the same level as that of a smoker. A study in New Zealand found that exposure to second-hand smoke increases the risk of stroke by 82 per cent in non-smokers. This is a serious concern, as stroke is such a common condition. Moreover, around 3.4 million people in the UK have asthma and for most of these, tobacco smoke is a trigger for an asthma attack. For someone with asthma, just one hour of exposure to second-hand smoke can cause a 20 per cent deterioration in lung function. During pregnancy, breathing in second-hand smoke increases the risk of having a baby with a low birth weight. Small babies are at much greater risk of infections and other health problems. A recent review of international research on the immediate health impact of smokefree workplace legislation found rapid and dramatic improvements. Air quality, respiratory health and levels of heart attacks and heart disease all improved substantially within months of the legislation being introduced.
1. There has been greater focus on the dangers of second-hand smoke since

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The field of 3-D printing comes with a new set of legal questions hospitals using the  technology will need to consider, said Bruce Kline, a technology licensing manager who oversees patents for new technology developed at Mayo Clinic. For starters, he said the STL file printers use are a lot like MP3 music files, in that they can be protected under copyright and require licensing to use. Copyright violations can occur if a purchased STL anatomical model file for rare disease is illegally shared with another institution that did not purchase the file from the vendor that created the file.  Under the law, if a device has a functional use it falls under patent law. If it is not functional, it falls under copyright law. Kline said most medical 3-D printing for educational models and complex anatomy evaluation currently falls under copyright. But, he said that will rapidly change in the coming years as customizable 3-D printable medical devices see wider use.  Additive manufacturing (AM) allows the creation of patient-specific devices at the point of care. Kline said an interesting fact is that these devices are FDA 510(k)-exempt if produced by a hospital instead of a medical device vendor. He said this blurs the lines between traditional vendor relationships, since the hospital can now become the manufacturer. However, if a hospital makes a device, it also becomes liable for it. He advised that it might be better for a commercial vendor to make the device for the hospital so the vendor assumes the liability of the device. Custom-made medical devices are also exempt under FDA regulations, Kline said. So, if a physician creates or modifies a device to meet the clinical needs of a specific patient’s anatomy, he said it is acceptable to use under current FDA rules. This may leave the door wide open for use of 3-D printed devices that are customized for each patient using their own 3-D imaging datasets.  It is possible printable device files may become available in the next few years to customize and print on demand. However, Kline said it will be much more difficult to enforce patents on these types of devices. He explained if someone makes one or two devices, there is no economical way for the creator of those device files to go after the user/maker of of unlicensed copies of the device to claim lost profits.
6. According to paragraph 3, what is NOT one of the changes the AM technologyintroduces to hospital?

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A (1) ______ teacher can reach thousands of students in an online course, opening up a world of knowledge to anyone with an internet connection. This limitless reach also offers substantial benefits for school districts that need to save money, by reducing the number of teachers. (2) __________, in high schools and colleges, there is mounting evidence that the growth of online education is hurting a critical group: the less proficient students (3) _______ are precisely those most in need of skilled classroom teachers. Online courses can be broken down into several categories, and some are more effective than others. In “blended” courses, for example, students don’t do their work only online: They also spend time in a classroom with a flesh-and-blood teacher. Research suggests that students — at nearly all levels of achievement — do just as well in these blended classes as they do in traditional classrooms. In this model, online resources supplement traditional instruction but don’t replace it. In the fully online model, on the other hand, a student may never be in the same room with an instructor. This category is the main problem. It is where less proficient students tend to (4) _________ trouble. After all, taking a class without a teacher requires high levels of self-motivation, self-regulation and organization. Yet, in high schools across the country, students who are struggling in (5) ________classrooms are increasingly steered into online course