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Nowadays, dozens of interventions are known that extend the lifespan of various living organisms ranging from yeast to mammals. They include chemical compounds, genetic interventions, and diets. Some targets of these interventions have been discovered. However, there is still no clear understanding of the systemic molecular mechanisms leading to lifespan extension. A group of scientists from Skoltech, Moscow State University and Harvard University decided to fill this gap and identify crucial molecular processes associated with longevity. To do so, they looked at the effects of various lifespan-extending interventions on the activity of genes in a mouse, a commonly used model organism closely related to humans. “In our lab, we subjected mice of different sexes and ages to 8 longevity interventions and analyzed gene expression changes induced by these treatments. After aggregating our data with the datasets published by other groups, we obtained gene activity profiles of 17 interventions. Although in general the effects produced by individual treatments turned out to be rather specific, a certain group of genes changed its expression in a similar way in response to different lifespan-extending interventions,” says the first author of the study, Alexander Tyshkovskiy. The scientists then applied the discovered biomarkers to search for other interventions with the same effect on their activity and, therefore, high potential for lifespan extension "Currently, we are validating these hits by testing their effect on the mouse lifespan. We hope that our biomarkers will significantly facilitate the search for new longevity interventions and help improve the healthspan and lifespan in rodents and, in the long term, in humans," says Alexander. 
1. The passage mainly discusses _________

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The annual mortality burden in the UK from exposure to outdoor air pollution is equivalent to around 40,000 deaths. To this can be (1) ____ further impacts from exposure to indoor air pollutants such as radon and second-hand smoke. The health problems resulting from exposure to air pollution also have a (2) ____ cost to society and business, our health services, and people who suffer from illness and premature death. In the UK, these costs add up to more than £20 billion every year. Vulnerable people are prisoners of air pollution, having to stay indoors and limit their (3) ____when pollution levels are high. This is not only unjust; it carries a cost to these individuals and the community from missed work and school, from more health problems (4) ____ lack of exercise, and from social isolation. Taking action will reduce pain, suffering and demands on the National Health Service (NHS), while (5) ____ people back to work, learning, and an active life. The value of these benefits far exceeds the cost of reducing emissions

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Pick any day in the Piazza del Duomo in the Italian city of Pisa, and you will  undoubtedly spot a bunch of tourists posing for the same photo: hands outstretched towards the cathedral’s conspicuously tilting bell tower, as if they are supporting it with their sheer strength. The so-called Leaning Tower of Pisa is one of the most famous buildings in the world, although maybe not for the reasons its original architects would have wanted.  In 1173, construction began on a white marble bell tower for the cathedral complex in Pisa, located between the Arno and Serchio rivers in Tuscany, central Italy. By the time builders had finished the third of eight planned stories about five years later, the tower’s foundation had begun to settle unevenly on the ground beneath it, a dense mixture of clay, sand and shells. As a result, the structure had begun to tilt visibly toward the south. Shortly after that, war broke out between Pisa and Genoa, another Italian city-state, halting construction for nearly a century. This delay allowed the foundation to settle further, likely prevented the bell tower’s premature collapse.  When construction resumed, chief engineer Giovanni di Simone tried to compensate for the lean by adding extra masonry to the short side, but the additional weight caused the structure to tilt even further. The tower was officially completed around 1370, but its lean only increased over the next six centuries, becoming an integral part of the monument’s quirky appeal. Despite various attempts to reinforce it, Pisa’s tower continued to subside at a rate of some 0.05 inches per year, placing it in increasing danger of collapse. By 1990, it was leaning 5.5 degrees (or some 15 feet) from the perpendicular–the most extreme angle yet. That year, the monument was closed to visitors and the bells removed as engineers started extensive reparations to stabilize it. By siphoning earth from beneath and adding counterweights to the tower’s north end, they were able to reduce the lean to 13.5 feet, or 4.0 degrees from perpendicular. The straightening continued after the tower reopened in 2001, and in 2008 sensors showed the subsiding motion had stopped, after a total improvement of some 19 inches. Engineers now believe the Leaning Tower of Pisa will remain stable for some 200 years, barring an earthquake or other unpredictable disaster. 
6. The word “barring” in paragraph 4 is closest in meaning to _______.

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While trust in media as a whole may be at an all-time low, a new study by the EBU has shown the public’s trust in traditional media (broadcast and the written press) is actually on the rise. However, people’s trust in new media continues to fall: 61% of European countries distrust the internet while 97% have no faith in social networks. The EBU’s new report – Trust in Media 2018 – shows the figures illustrating the differences between people’s trust in traditional and new media. Broadcast media remain the most trusted forms of media with 59% of people tending to trust radio (equivalent to 2017) and 51% trusting TV in the EU (an increase of 1 percentage point on 2017). Trust in the written press has also slowly improved over the last 5 years and it is now trusted by 47% of EU citizens. At the same time, people’s trust in the internet and social media has been eroded by fake news, misinformation and disinformation. Only 34% of EU citizens trust the internet and a mere 20% now trust social networks (down from 36% and 21% respectively in 2017). Trust in Media 2018 is based on data published in the 88th Eurobarometer survey and gives an idea of European citizens’ perception of the trustworthiness of different types of media. The survey consists of approximately 1000 face-to-face interviews in the 33 countries covered by the study. The report shows how European citizens’ trust in broadcast media is closely connected with a free and independent press. The higher the level of trust in a country’s radio and TV, the higher press freedom in that country tends to be. There are also strong regional differences with the Nordics and Albania tending to trust traditional media the most while Eastern Europeans tend to trust social networks and the internet more. The EBU’s Head of Strategy and the Media Intelligence Service Roberto Suárez Candel said: “The results of our research show that good quality, impartial media is highly valued by the public. “Public service media play an important role in that and, together, our Members make an invaluable contribution to society. The role of our public service Members in upholding democratic values and supporting media freedom is clearly demonstrated by the results of our research.”  
5. According to paragraph 3, all the statements can be supported by the research, EXCEPT ____

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Leisure reading, also known as recreational reading, pleasure reading, free voluntary reading, and independent reading, is independent, self-selected reading of a continuous text for a wide range of personal and social (1)__________. It can take place in and out of school, at any time. Readers (2)__________from a wide range of extended texts, including but not exclusive to narrative fiction, nonfiction, picture books, e-books, magazines, social media, blogs, websites, newspapers, comic books, and graphic novels. Leisure reading is (3)_______intrinsically or socially motivated and a pleasurable activity for the reader. Students’ home environment, where parents/caregivers encourage reading and model their enjoyment of reading, has a substantial (4)___________impact on children’s performance in reading. In classrooms, leisure reading often takes place during times designated as SSR (sustained silent reading), DEAR (drop everything and read), LTR (love to read), or POWER (providing opportunities with everyday reading), which are the most common terms for classroom leisure reading. It may take place (5) _____individual classrooms or be part of a school-wide activity

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I felt nervous when the teacher said she __________ my school report home soon.

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After working hard for hours, the farmers sat down and ___________ a short rest.

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The hotel where we are __________ is quite luxurious.

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Because the low latitudes of the Earth, the areas near the equator, receive more heat than the latitudes near the poles, and because the nature of heat is to expand and move, heat is transported from the tropics to the middle and high latitudes. Some of this heat is moved by winds and some by ocean currents, and some gets stored in the atmosphere in the form of latent heat. The term “latent heat” refers to the energy that has to be used to convert liquid water to water vapor. We know that if we warm a pan of water on a stove, it will evaporate, or turn into vapor, faster than if it is allowed to sit at room temperature. We also know that if we hang wet clothes outside in the summertime they will dry faster than in winter, when temperatures are colder. The energy used in both cases to change liquid water to water vapor is supplied by heat – supplied by the stove in the first case and by the Sun in the latter case. This energy is not lost. It is stored in water vapor in the atmosphere as latent heat. Eventually, the water stored as vapor in the atmosphere will condense to liquid again, and the energy will be released to the atmosphere. In the atmosphere, a large portion of the Sun’s incoming energy is used to evaporate water, primarily in the tropical oceans. Scientists have tried to quantify this proportion of the Sun’s energy. By analyzing temperature, water vapor, and wind data around the globe, they have estimated the quantity to be about 90 watts per square meter, or nearly 30 percent of the Sun’s energy. Once this latent heat is stored within the atmosphere, it can be transported, primarily to higher latitudes, by prevailing, large-scale winds. Or it can be transported vertically to higher levels in the atmosphere, where it forms clouds and subsequent storms, which then release the energy back to the atmosphere
1. The passage mainly discusses how heat ______________

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Few political and social issues generate as much passion and controversy as immigration. One of the most prominent concerns among anti-immigration campaigners is the idea that immigration breaks down the host society’s cultural traditions and harms its cultural identity. Central to these debates is what academics call “acculturation”. This term refers to behavioural or psychological changes in immigrants or their descendants that follow migration. They are typically changes that make behaviour or ways of thinking more similar to members of the adopted society. Recent studies typically measure behavioural or psychological traits in first generation migrants, second generation migrants, and non-migrants who have been living in the host area for several generations. The evidence suggests that acculturation is common, but generational. While first generation migrants typically retain the values of their society of origin, later generations shift about 50% of the way from their parents’ values towards nonmigrant values. This even occurs in communities that form large, cohesive minorities. Migration with no acculturation breaks down distinct host cultures. This is the scenario envisioned by anti-immigration campaigners. Even a little migration, without acculturation, soon creates a homogeneous worldwide blend of the cultural traits that were originally unique to different societies. But adding just a small amount of acculturation to the simulations could preserve cultural differences. For example, even for relatively high migration rates where ten per cent of the society migrates in each time period, just a 20% probability of acculturation is needed to maintain distinct cultural variation between societies. This suggests that the 50% acculturation level observed in the real-world is strong enough to preserve distinct cultures.  These results held for both “neutral” traits such as dress or dance, and for costly cooperative traits, such as building bridges or paying taxes, where individuals pay initial costs to benefit the entire society. Much concern over immigration centres on the latter – that immigrants take benefits without paying costs. There were, however, levels of migration at which no level of acculturation could preserve cultural traditions. When 50% or more of the societies migrate, then distinct traditions cannot be maintained. While this exceeds modern levels of migration, we might think of historical cases of colonisationas examples where high levels of migration broke down traditions. Whatever future research finds, it would surely be better if immigration policy and media coverage of immigration, were better informed by the available evidence concerning migrant acculturation  
2. The word “its” in paragraph 1 refers to _____

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In the United States, presidential elections are held in years evenly divisible by four (1888, 1900, 1964, etc.). Since 1840, American presidents elected in years ending with zero have died in office, with one exception. William H. Harrison, the man who served the shortest term, died of pneumonia only several weeks after his inauguration.
Abraham Lincoln was one of four presidents who were assassinated. He was elected in 1860, and his untimely death came just five years later. James Garfield, a former Union army general from Ohio, was shot during his first year in office (1881) by a man to whom he wouldn’t give a job. While in his second term of office (1901), William McKinley, another Ohioan, attended the Pan-American Exposition in Buffalo, New York. During the reception, he was assassinated while shaking hands with some of the guests. John F. Kennedy was assassinated in 1963 in Dallas only three years after his election.
Three years after his election in 1920, Warren G, Harding died in office. Although it was never proved, many believe he was poisoned. Franklin Roosevelt was elected four times (1932, 1936, 1940 and 1944), the only man to serve so long a term. He had contracted polio in 1921 and eventually died of the illness in 1945.
Ronald Reagan, who was elected in 1980 and reelected four years later, suffered an assassination attempt but did not succumb to the assassin’s bullets. He was the first to break the long chain of unfortunate events. Will the candidate in the election of 2020 also be as lucky?

How long did Warren G, Harding work as a president?

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I_______ in the lounge for ten minutes.

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Your body will change in shape and________

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Climate change, also called global warming, refers to the rise in average surface temperatures on Earth. An overwhelming scientific consensus maintains that climate change is due primarily to the human use of fossil fuels, which (1) __________ carbon dioxide and other greenhouse gases into the air. The gases trap heat within the atmosphere, which can have a range of effects on ecosystems, (2) __________ rising sea levels, severe weather events, and droughts that render landscapes more susceptible to wildfires. While consensus among nearly all scientists, scientific organizations, and governments is (3)__________ climate change is happening and is caused by human activity, a small minority of voices questions the validity of such assertions and prefers to cast doubt on the preponderance of evidence. Climate change deniers often claim that recent changes (4) __________ to human activity can be seen as part of the natural variations in Earth’s climate and temperature, and that it is difficult or impossible to establish a direct connection between climate change and any single weather event, such as a hurricane. While the latter is generally true, decades of data and analysis support the reality of climate change and the human factor in this process. In any case, economists agree that acting to reduce fossil fuel emissions would be far less expensive than (5) __________ with the consequences of not doing so

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People who do not smoke, are not obese, and consume alcohol moderately can expect to live seven years longer than the general population, and to spend most of these extra years in good health, according to a new study published today in Health Affairs. This study was the first to analyze the cumulative impact of several key health behaviours on disability-free and total life expectancy. Previous studies have looked at single health behaviours. Mikko Myrskylä and his colleague instead examined several behaviors simultaneously, which allowed them to determine how long and healthy the lives of people who had avoided most of the well-known individual behavioral risk factors were. The researchers noted that each of the three unhealthy behaviours – obesity, smoking, and unhealthy consumption of alcohol – was linked to a reduction in life expectancy and to an earlier occurrence of disabilities. But there were also differences: smoking was found to be associated with an early death but not with an increase in the number of years with disability, whereas obesity was shown to be associated with a long period of time with disability. Excessive alcohol consumption was found to be associated with both decreased lifespan and a reduced number of healthy years. However, the absence of all of these risky healthy behaviors was found to be associated with the greatest number of healthy years. The most striking finding was the discovery of a large difference in average lifespan between the groups who were the most and the least at risk. Men who were not overweight, had never smoked, and drank moderately were found to live an average of 11 years longer than men who were overweight, had smoked, and drank excessively. For women, the gap between these two groups was found to be even greater, at 12 years. “Our results show how important it is to focus on prevention. Those who avoid risky health behaviours are achieving very long and healthy lives. Effective policy interventions targeting health behaviors could help larger fractions of the population to achieve the health benefits observed in this study,” the researcher emphasized. These results are important not only for individuals, but also for society. In an aging society, the health of the elderly determines the amount of money spent on the health system. In addition, healthy elderly people are better able to participate in the labor market and to perform social roles, such as caring for grandchildren.  
5. The word “them” in paragraph 2 refers to _____

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I am sorry that I can't ________ your invitation.

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Common methods of deforestation are burning trees and clear cutting. These tactics leave the land completely barren and are controversial practices. Clear cutting is when large swaths of land are cut (1) ______ all at once. A forestry expert quoted by the Natural Resources Defense Council describes clear cutting as “an ecological trauma that has no precedent in nature (2) _____ for a major volcanic eruption.” Burning can be done quickly, in vast swaths of land, or more slowly with the slash-andburn technique. Slash-and-burn agriculture entails cutting down a patch of trees, (3) __________ them and growing crops on the land. The ash from the (4) _____ trees provides some nourishment for the (5) ______ and the land is weed-free from the burning. When the soil becomes less nourishing and weeds begin to reappear over years of use, the farmers move on to a new patch of land and begin the process again

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Spend just a minute watching the world population counter tick up on Worldometers and you’ll see just how quickly we’re swelling in numbers. The current figure stands at around 7.7 billion, and this is projected to become 9.8 billion by 2050, according to the UN. More people means more carbon footprints - more cars, waste and emissions, more houses and infrastructure to be constructed using the world’s limited resources, more mouths to be fed using more water and energy in food production. Governments recognise the severity of the situation and have mostly come together over global policies like the UN’s Paris Agreement, to limit carbon emissions and their impact on climate change. In addition, new technologies are being developed to make our use of resources more efficient. As for controlling population growth, the education of women is one key factor. Research shows the higher level to which a woman is educated, the fewer children she is likely to have. In Ghana, for example, women who have been to high school, have a fertility rate of between two and three children, compared with six for those who have no education. This could be for several reasons including learning about desired family size and understanding child health better. This means that the mother is more confident her children will survive. She is also likely to hold more sway within the family, arguing for fewer children if that is what she wants.  There is also plenty that individuals can do to reduce their personal footprint. Earth Overshoot Day is defined as the day when humanity has used up nature’s resource budget for the year. The Global Footprint Network calculates that moving Earth Overshoot day back by five days every year would mean that, by 2050, we’d be using the resources of less than one planet. Just eating 50% less meat and replacing it with vegetarian alternatives could save the planet five days. As David Attenborough says, if we want to save Earth, we can no longer afford to keep eating meat: “We are omnivores, so biologically, if you could have a biological morality, you can say, yes we evolved to eat pretty well everything. But now we’ve got to a stage in our own social evolution in which that is no longer practical.” Sir David says he himself now eats less meat and is bolstered by the knowledge that it’s helping the planet.  
8. Which of the following can be inferred from the passage?

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The aviation industry, especially the commercial aviation sector, is constantly striving to improve both the way it works and its customer satisfaction. It has begun using artificial intelligence. Though AI in the aviation industry is still in the nascent stage, some progress has been made already as certain leading carriers invest in AI. To make a long story short, AI can redefine how the aviation industry goes about its work. In 2017, American Airlines conducted an app development competition with the goal of having an app developed for making baggage screening easier for passengers. The competition, named HackWars, was themed upon artificial intelligence, drones and augmented and virtual reality. The winner, known as “Team Avatar,” developed an app that would not only allow passengers determine their baggage size before arriving at the airport, but also prepay any potential baggage-related expenses. United Airlines is using Amazon’s Alexa to have certain common customer queries answered. In September 2017, United announced a collaboration with Alexa. The feature is known as the United skill. To get started, all passengers need to do is to  add the United skill to their Alexa app and then start asking questions. Alexa answers common queries correctly, such as the status of a flight by number, check-in requests and availability of Wi-Fi on a flight. The reviews so far have been mixed, which points to the fact that there is a learning curve, and it is still a long way to go before AI can fully handle customer assistance. Tracking progress is an enormous challenge that airlines will face. The first thing they need to do is to develop analytics that will help them develop and process accurate data. However, that in itself is a challenge. What kind of analytics will help? For example, customer satisfaction is going to be one of the most important factors in success. What kind of analytics will determine that airlines have been improving on customer satisfaction parameters? AI needs huge investments, and probably the biggest risk in this is smaller, especially budget airlines are going to miss out on reaping the benefits of AI fully. Does that mean that the performance of the smaller carriers will be impacted? That might not be the case, because we might be moving toward more acquisitions and mergers. Bigger airlines will have a massive appetite for acquiring smaller airlines with an eye on the market. It is not all gloom and doom though, because smaller airlines like Southwest have already shown some initiatives toward embracing AI. It is surprising that a sector as important as aviation has woken up to AI so late. As AI in aviation picks up its pace, there could probably be a few mergers, acquisitions or even closure of small airlines which will not be able to afford the investments. Now, AI seems the best option to take aviation to the next level.
3. What does author want to convey in paragraph 2?

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All families face challenges and hurdles as a normal part of life and getting through these times requires respectful communication and care for each other. However, some families face significant (1) _______ like not having a place to live, a parent going to court, a parent having a long-term illness, or parents having to work (2) ________ from home or for long hours.  Some families seem to fight and argue a lot, which can be really scary and stressful. Sometimes, family relationships can be so stressful that you feel unsafe and scared. These types of things make relationships (3) _________ and negative and it can make it difficult to feel like talking things through.  As a teenager you are going through a lot of changes within yourself physically, mentally, emotionally and socially. Often these changes (4) _________ at different rates and at different times. It is important for you to be aware of what is going on and how this may affect you at school, home and/or around family and friends having an understanding of adolescent development can be very (5) _____

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If you want to improve group productivity, it is advisable that you organize competitions that build morale and teamwork skills for all participants, (1) _______ than just a few star performers. For example, if you (2) _______ a competition between sales teams, you can reward all members of the (3) _______ group with a lunch out at a nice restaurant or a group trip. This way, even the lower-performing members of the team have a reason to try as hard as they can to help the team win. In an individual sales contest, a few top salespeople compete with one another for the top prize, (4) _______ everyone else gives up because they know they can’t win. The productivity of (5) _______ top people increases, but the productivity of the rest of the group does not. In a team competition, even the lowestperforming member of the group can help earn the prize, so all team members put in their best effort and the productivity of the entire group goes up